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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Crimea Journal of Experimental and Clinical Medicine</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Crimea Journal of Experimental and Clinical Medicine</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Крымский журнал экспериментальной и клинической медицины</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2224-6444</issn>
   <issn publication-format="online">2224-6452</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">106790</article-id>
   <article-id pub-id-type="doi">10.29039/2224-6444-2025-15-2-24-31</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>ORIGINAL ARTICLES</subject>
    </subj-group>
    <subj-group>
     <subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">THE EFFECTIVENESS OF SANATORIUM TREATMENT OF PATIENTS WITH BRONCHIAL ASTHMA AFTER COVID-19 IN THE CONDITIONS OF THE SOUTHERN COAST OF CRIMEA</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ЭФФЕКТИВНОСТЬ САНАТОРНО-КУРОРТНОГО ЛЕЧЕНИЯ БОЛЬНЫХ С БРОНХИАЛЬНОЙ АСТМОЙ В ПОСТКОВИДНОМ ПЕРИОДЕ В УСЛОВИЯХ ЮЖНОГО БЕРЕГА КРЫМА</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Дудченко</surname>
       <given-names>Л. Ш.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Dudchenko</surname>
       <given-names>L. Sh.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Белоглазов</surname>
       <given-names>В. А.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Beloglazov</surname>
       <given-names>V. A.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Кумельский</surname>
       <given-names>Е. Д.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kumel'skiy</surname>
       <given-names>E. D.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Яцков</surname>
       <given-names>И. А..</given-names>
      </name>
      <name xml:lang="en">
       <surname>Yackov</surname>
       <given-names>I. A..</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Корзинина</surname>
       <given-names>А. В.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Korzinina</surname>
       <given-names>A. V.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Академический научно исследовательский институт физических методов лечения, медицинской климатологии и реабилитации имени  И. М. Сеченова</institution>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Академический научно исследовательский институт физических методов лечения, медицинской климатологии и реабилитации имени  И. М. Сеченова</institution>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Крымский федеральный университет имени В.И.Вернадского</institution>
    </aff>
    <aff>
     <institution xml:lang="en">Crimean Federal University of a name of V.I.Vernadsky</institution>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2025-11-18T00:00:00+03:00">
    <day>18</day>
    <month>11</month>
    <year>2025</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2025-11-18T00:00:00+03:00">
    <day>18</day>
    <month>11</month>
    <year>2025</year>
   </pub-date>
   <volume>15</volume>
   <issue>2</issue>
   <fpage>24</fpage>
   <lpage>31</lpage>
   <history>
    <date date-type="received" iso-8601-date="2025-11-18T00:00:00+03:00">
     <day>18</day>
     <month>11</month>
     <year>2025</year>
    </date>
   </history>
   <self-uri xlink:href="https://docs.yandex.ru/docs/view?url=ya-browser%3A%2F%2F4DT1uXEPRrJRXlUFoewruIZJze7_EeJ-FfBybO7XgIKFONtpjiU8T9mKfVkH8NxG0Hz_U3OlCCRWhmys8aqeh8qfE4AkEyhUrRD5uv9i-cab6MCPV6VH3wSSncHxPSsEmNvAjoZihXC4TtCAkcIQIA%3D%3D%3Fsign%3DGiCxV-X0eAgyxxjErMoR5t4S81_I4sVKS7blCObsKgU%3D&amp;name=3_&#x414;&#x443;&#x434;&#x447;&#x435;&#x43D;&#x43A;&#x43E;-1.doc&amp;nosw=1">https://docs.yandex.ru/docs/view?url=ya-browser%3A%2F%2F4DT1uXEPRrJRXlUFoewruIZJze7_EeJ-FfBybO7XgIKFONtpjiU8T9mKfVkH8NxG0Hz_U3OlCCRWhmys8aqeh8qfE4AkEyhUrRD5uv9i-cab6MCPV6VH3wSSncHxPSsEmNvAjoZihXC4TtCAkcIQIA%3D%3D%3Fsign%3DGiCxV-X0eAgyxxjErMoR5t4S81_I4sVKS7blCObsKgU%3D&amp;name=3_Дудченко-1.doc&amp;nosw=1</self-uri>
   <abstract xml:lang="ru">
    <p>Контролируемое течение бронхиальной астмы (БА) в исследованиях отмечается у 25-68% пациентов, однако, в реальной клинической практике, вероятно, данный уровень значительно ниже. Санаторно-курортное лечение является перспективным методом увеличения контроля БА, однако данные о его влиянии на различные звенья патогенеза астмы скудны. Цель. Оценка влияния санаторно-курортного лечения на клиникофункциональные показатели и состояние системного воспаления у больных с БА в постковидном периоде в условиях Южного берега Крыма. Материалы и методы. В исследование были включены пациенты с диагнозом БА. Пациенты (n=73) проходили санаторно-курортное лечение в отделении пульмонологии АНИИ им. Сеченова в г. Ялта. Перед поступлением и после проведения санаторно-курортного лечения, был произведен опрос по шкале AQLQ, а также выполнен забор плазмы крови с целью дальнейшего проведения его анализа. Изучали уровень эозинофилов и С-реактивного белка. Также были проведены функциональные исследования, в частности, пульсоксиметрия (SpO2), спирография с определением форсированной жизненной ёмкости лёгких (ФЖЕЛ), объема форсированного выдоха за первую секунду (ОФВ1), соотношение ОФВ1/ФЖЕЛ, тест с 6-минутной ходьбой (Т6МХ). Результаты. Санаторно-курортное лечение положительно повлияло на уровень качества жизни больных с астмой. Так, интегральный показатель AQLQ увеличился с 4,18 баллов до 4,38 баллов. Были выявлены улучшения показателей внешнего дыхания. ФЖЕЛ увеличилась с 92,3% до 95,9% (p = 0,01), ОВФ1 возрос с  78,1% до 82,1%, (p = 0,001). Уровень СРБ достоверно не менялся. Заключение. Санаторно-курортное лечение больных с БА в постковидном периоде в условиях ЮБК является эффективным методом для поддержания должного уровня контроля БА вне обострений, однако не влияет на уровень системного воспаления, что требует дополнительного изучения и разработки новых подходов к методикам санаторно-курортного лечения.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>A controlled bronchial asthma (BA) has been observed in studies in 25-68% of patients, however, in clinical practice, this level is likely to be lower. Spa treatment is a promising method of increasing the control of BA, however, data  on its effect on various links of pathogenesis of asthma are scarce. The aim to evaluate the effect of spa treatment on clinical and functional parameters and systemic inflammation in patients with BA in the postcovid period in conditions of Southern coast of Crimea. Material and methods. Patients (n=73) with BA underwent spa treatment in the Sechenov Institution in Yalta. Before and after treatment, an AQLQ scale survey was conducted. The levels of eosinophils and C-reactive protein (CRP) were studied. Functional studies were also conducted, pulse oximetry (SpO2), spirography with the evaluation of forced vital capacity (LVEF), forced expiratory volume in the first second (OFV1), the ratio of OFV1/VVC, a test with 6-minute walking (T6MX). Results. Sanatorium treatment has had a positive effect on the life quality of patients with asthma. Integral indicator of AQLQ increased from 4.18 points to 4.38 points. Improvements in respiratory parameters were revealed. VVC increased from 92.3% to 95.9% (p = 0.01), OVF1 increased from 78.1% to 82.1% (p = 0.001). The level of CRP did not significantly change. Conclusion. Spa treatment of patients with BA in the postcovid period is effective method for maintaining an adequate level of asthma control, however, it does not affect the level of systemic inflammation, which requires additional study.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>бронхиальная астма</kwd>
    <kwd>санаторно-курортное лечение</kwd>
    <kwd>COVID-19</kwd>
    <kwd>Южный  берег Крыма</kwd>
    <kwd>системное воспаление</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>bronchial asthma</kwd>
    <kwd>sanatorium treatment</kwd>
    <kwd>COVID-19</kwd>
    <kwd>Southern coast of Crimea</kwd>
    <kwd>systemic inflammation.</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
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