Tavricheskiy Mediko-Biologicheskiy Vestnik Tavricheskiy Mediko-Biologicheskiy Vestnik Таврический медико-биологический вестник 2070-8092 53965 10.29039/2070-8092-2020-23-4-20-26 Оригинальные статьи Original articles Оригинальные статьи CHANGES IN THE QT INTERVAL IN PATIENTS WITH ANKYLOSING SPONDYLITIS ИЗМЕНЕНИЕ ИНТЕРВАЛА QT У БОЛЬНЫХ АНКИЛОЗИРУЮЩИМ СПОНДИЛИТОМ Заяева А. А. Zayaeva A. A. Кошукова Галина Николаевна Koshukova Galina Nikolaevna Доля Е. М. Dolya E. M. Николаева А. П. Nikolayeva A. P. Тен Д. И. Ten D. I. Крымский федеральный университет имени В.И.Вернадского Crimean Federal University of a name of V.I.Vernadsky Крымский Федеральный Университет им. В.И. Вернадского RU V.I. Vernadsky Crimean Federal University RU Республиканская клиническая больница имени Н.А.Семашко Россия Республиканская клиническая больница имени Н.А.Семашко Russian Federation 21 10 2022 21 10 2022 23 4 20 26 20 10 2022 https://ma.cfuv.ru/site/page/show/docid/260975

Анкилозирующий спондилит вызывает морфологическое или функциональное поражение сердечно- сосудистой системы в 22% случаях. Применение современных методов исследования функции сердца, таких как холтеровское мониторирование ЭКГ, позволяется выявлять нарушения ритма и проводимости, синдром удлиненного интервала QT. Изменение параметров интервала QT, таких как его продолжительность и дисперсия, можно рассматривать как предиктор развития кардиоваскулярных катастроф, фатальных аритмий. В статье проведен анализ величин QT/RR и QTc при проведении Холтеровского мониторирования ЭКГ у 92 пациентов с диагнозом Анкилозирующий спондилит в зависимости от стадии заболевания, активности патологического процесса, серопозитивности по HLA B27. Установлено достоверное увеличение QT/RR и QTс за активный и пассивный периоды проведения Холтеровского мониторирования ЭКГ в сравнении с группой контроля. У пациентов с анкилозирующим спондилитом выявлены желудочковые нарушения ритма, которые взаимосвязаны с удлинением интервала QT. Стандартизированное проведение у больных с АС Холтеровского мониторирования ЭКГ, с учетом суточной дисперсии интервала QT может стать универсальным, малоинвазивным и низкозатратным методом оценки риска развития кардиоваскулярных нарушений у пациентов с Анкилозирующим спондилитом.

Ankylosing spondylitis causes morphological or functional damage to the cardiovascular system in 22% of cases. Using modern methods of heart function research, such as Holter ECG monitoring, it is possible to detect rhythm and conduction disorders, long QT syndrome. Changes in the parameters of the QT interval, such as its duration and variance, can be considered as a predictor of the development of cardiovascular catastrophes and fatal arrhythmias. The article analyzes the values of QT/RR and QTc during Holter ECG monitoring in 92 patients diagnosed with Ankylosing spondylitis, depending on the stage of the disease, the activity of the pathological process, and seropositivity for HLA B27. There was a significant increase in QT/RR and QTc during the active and passive periods of Holter ECG monitoring in comparison with the control group. In patients with ankylosing spondylitis, ventricular arrhythmias were detected, which are associated with prolongation of the QT interval. Standardized Holter ECG monitoring in patients with Ankylosing spondylitis, taking into account the daily variance of the QT interval, can become a universal, minimally invasive and low-cost method for assessing the risk of cardiovascular disorders in patients with Ankylosing spondylitis.

 анкилозирующий спондилит интервал QT Холтеровское мониторирование ЭКГ ankylosing spondylitis QT interval Holter ECG monitoring

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