<?xml version="1.0"?>
<!DOCTYPE article
PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20190208//EN"
       "JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.4" xml:lang="en">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Tavricheskiy Mediko-Biologicheskiy Vestnik</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Tavricheskiy Mediko-Biologicheskiy Vestnik</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Таврический медико-биологический вестник</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2070-8092</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">54718</article-id>
   <article-id pub-id-type="doi">10.29039/2070-8092-2020-23-4-105-112</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>Обзоры</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>Reviews</subject>
    </subj-group>
    <subj-group>
     <subject>Обзоры</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">HEART DAMAGE AS ONE OF THE SYNDROM OF COVID-19 INFECTION</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ПОРАЖЕНИЕ СЕРДЦА КАК ОДИН ИЗ СИНДРОМОВ COVID-19 ИНФЕКЦИИ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Мурейко</surname>
       <given-names>Е. А.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Mureyko</surname>
       <given-names>E. A.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Калиберденко</surname>
       <given-names>В. Б.</given-names>
      </name>
      <name xml:lang="en">
       <surname>Kaliberdenko</surname>
       <given-names>V. B.</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Крымский Федеральный Университет им. В.И. Вернадского</institution>
     <country>RU</country>
    </aff>
    <aff>
     <institution xml:lang="en">V.I. Vernadsky Crimean Federal University</institution>
     <country>RU</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2022-10-21T11:49:11+03:00">
    <day>21</day>
    <month>10</month>
    <year>2022</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2022-10-21T11:49:11+03:00">
    <day>21</day>
    <month>10</month>
    <year>2022</year>
   </pub-date>
   <volume>23</volume>
   <issue>4</issue>
   <fpage>105</fpage>
   <lpage>112</lpage>
   <history>
    <date date-type="received" iso-8601-date="2022-10-21T00:00:00+03:00">
     <day>21</day>
     <month>10</month>
     <year>2022</year>
    </date>
   </history>
   <self-uri xlink:href="https://ma.cfuv.ru/site/page/show/docid/261001">https://ma.cfuv.ru/site/page/show/docid/261001</self-uri>
   <abstract xml:lang="ru">
    <p>В  настоящее  время  наиболее  острой  и  серьезной  проблемой  во  всем  мире  является пандемия, вызванная коронавирусной инфекцией. Известно, что вирус повреждает альвеоциты легких, вызывая пневмонию и/или острый респираторный дистресс синдром. Однако, не только легкие являются мишенью поражения SARS-CoV-2. В статье представлен обзор случаев поражения сердца при COVID-19 инфекции. Нами были изучены зарубежные и отечественные научные публикации, касающиеся случаев поражения сердечно-сосудистой системы в целом, и сердца в частности. Изучение, анализ и обзор данных проводился  в период с декабря 2019 года по июнь 2020 года. Научные работы по данной теме были найдены на таких платформах, как PubMed, Europe PubMed Central, Elsevier Science Direct, Elsevier Open Science, Springer Open, Bielefeld Academic Search Engine и Научная электронная библиотека eLibrary.ru.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Currently, pandemic caused by coronavirus infection is the most acute and serious problem in the world. It’s known that the virus damage`s the alveocytes of the lungs, causing pneumonia and / or acute respiratory distress syndrome. However, it is not only the lungs are targeted by SARS-CoV-2. The article provides an overview of cases of heart damage in sick sufferers COVID-19 infection. We have studied foreign and domestic scientific publications concerning cases of damage to the cardiovascular system in general, and the heart in particular. The study, analysis and review of the data was carried out from December 2019 to June 2020. Scientific papers on this topic have been found on platforms such as PubMed, Europe PubMed Central, Elsevier Science Direct, Elsevier Open Science, Springer Open, Bielefeld Academic Search Engine, and Scientific electronic library eLibrary.ru.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>COVID-19</kwd>
    <kwd>поражение сердца</kwd>
    <kwd>тропонин</kwd>
    <kwd>миоглобин</kwd>
    <kwd>NT-proBNP</kwd>
    <kwd>COVID-19 инфекция</kwd>
    <kwd>SARS-CoV-2</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>COVID-19</kwd>
    <kwd>heart damage</kwd>
    <kwd>troponin</kwd>
    <kwd>myoglobin</kwd>
    <kwd>NT-proBNP</kwd>
    <kwd>COVID-19 infection</kwd>
    <kwd>SARS- CoV-2</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Информационные  ресурсы  Министерства здравоохранения РФ для мониторинга эпидемиологической обстановки по COVID-19. Доступно по:  https://covid19.rosminzdrav.ru/  Ссылка  активна на 05.10.2020.</mixed-citation>
     <mixed-citation xml:lang="en">Informacionnye  resursy  Ministerstva zdravoohraneniya RF dlya monitoringa epidemiologicheskoy obstanovki po COVID-19. Dostupno po:  https://covid19.rosminzdrav.ru/  Ssylka  aktivna na 05.10.2020.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Временные  методические  рекомендации диагностика, профилактика коронавирусной новой лечение и 19-covid инфекции [архив] Доступно  по:  https://static0.rosminzdrav.ru/system/ attachments/attaches/000/050/584/original/03062020_ МR_COVID-19_v7.pdf</mixed-citation>
     <mixed-citation xml:lang="en">Vremennye  metodicheskie  rekomendacii diagnostika, profilaktika koronavirusnoy novoy lechenie i 19-covid infekcii [arhiv] Dostupno  po:  https://static0.rosminzdrav.ru/system/ attachments/attaches/000/050/584/original/03062020_ MR_COVID-19_v7.pdf</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Наименование  заболевания,  вызванного коронавирусом (COVID-19), и вирусного возбу- дителя.  Всемирная  организация  здравоохранения. Дата обращения 27 июня 2020 [архив]. Доступно по:  https://www.who.int/ru/emergencies/diseases/ novel-coronavirus-2019/technical-guidance/naming- the-coronavirus-disease-(covid-2019)-and-the-virus- that-causes-i</mixed-citation>
     <mixed-citation xml:lang="en">Naimenovanie  zabolevaniya,  vyzvannogo koronavirusom (COVID-19), i virusnogo vozbu- ditelya.  Vsemirnaya  organizaciya  zdravoohraneniya. Data obrascheniya 27 iyunya 2020 [arhiv]. Dostupno po:  https://www.who.int/ru/emergencies/diseases/ novel-coronavirus-2019/technical-guidance/naming- the-coronavirus-disease-(covid-2019)-and-the-virus- that-causes-i</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Huang, C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., Xie X., Yin W., Li H., Liu M., Xiao Y., Gao H., Guo L., Xie J., Wang G., Jiang R., Gao Z., Jin Q., Wang J., Cao B. Clinical features of patients infected  with  2019  novel  coronavirus in Wuhan,  China.  Lancet.  2020;395:497-506.  doi: 10.1016/S0140-6736(20)30183-5.</mixed-citation>
     <mixed-citation xml:lang="en">Huang, C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., Xie X., Yin W., Li H., Liu M., Xiao Y., Gao H., Guo L., Xie J., Wang G., Jiang R., Gao Z., Jin Q., Wang J., Cao B. Clinical features of patients infected  with  2019  novel  coronavirus in Wuhan,  China.  Lancet.  2020;395:497-506.  doi: 10.1016/S0140-6736(20)30183-5.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Fang L., Wenhui L., Michael F., Stephen C.H. Structure of SARS coronavirus spike receptor-binding domain сomplexed with receptor. The Journal of Clinical Endocrinology  and  Metabolism.950;10(10):1361-2. doi:10.1126/SCIENCE.1116480.</mixed-citation>
     <mixed-citation xml:lang="en">Fang L., Wenhui L., Michael F., Stephen C.H. Structure of SARS coronavirus spike receptor-binding domain somplexed with receptor. The Journal of Clinical Endocrinology  and  Metabolism.950;10(10):1361-2. doi:10.1126/SCIENCE.1116480.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kuba K., Imai Y., Rao S., Gao H., Guo F., Guan B., Huan Y., Yang P., Zhang Y., Deng W., Bao L., Zhang B., Liu G., Wang Z., Chappell M., Liu Y., Zheng D., Leibbrandt A., Wada T., Slutsky A. S., Liu D., Qin C., Jiang C., Penninger J. M. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus induced lung injury. Nature Medicine. 2005;11(8):875- 9. doi: 10.1038/nm1267.</mixed-citation>
     <mixed-citation xml:lang="en">Kuba K., Imai Y., Rao S., Gao H., Guo F., Guan B., Huan Y., Yang P., Zhang Y., Deng W., Bao L., Zhang B., Liu G., Wang Z., Chappell M., Liu Y., Zheng D., Leibbrandt A., Wada T., Slutsky A. S., Liu D., Qin C., Jiang C., Penninger J. M. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus induced lung injury. Nature Medicine. 2005;11(8):875- 9. doi: 10.1038/nm1267.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Vaarala M. H., Porvari K. S., Kellokumpu S., Kyllцnen A. P., Vihko P. T. Expression of transmembrane serine  protease  TMPRSS2  in  mouse  and  human tissues.  Journal  of  Pathology.  2001;193(1):134-40. doi:10.1002/1096-9896(2000)9999:9999&lt;::AID- PATH743&gt;3.0.CO;2-T.</mixed-citation>
     <mixed-citation xml:lang="en">Vaarala M. H., Porvari K. S., Kellokumpu S., Kyllcnen A. P., Vihko P. T. Expression of transmembrane serine  protease  TMPRSS2  in  mouse  and  human tissues.  Journal  of  Pathology.  2001;193(1):134-40. doi:10.1002/1096-9896(2000)9999:9999&lt;::AID- PATH743&gt;3.0.CO;2-T.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Liu Y., Yan L., Wan L., Xiang T., Le A., Liu J.,Peiris J. S., Poon  L. M.,  Zhang  W.  Viral  dynamics in mild and severe cases of COVID-19. The Lancet Infectious  Diseases.  2019;  2020(20):2019-20. doi:10.1016/S1473-3099(20)30232-2</mixed-citation>
     <mixed-citation xml:lang="en">Liu Y., Yan L., Wan L., Xiang T., Le A., Liu J.,Peiris J. S., Poon  L. M.,  Zhang  W.  Viral  dynamics in mild and severe cases of COVID-19. The Lancet Infectious  Diseases.  2019;  2020(20):2019-20. doi:10.1016/S1473-3099(20)30232-2</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kwong J. C. , Schwartz K. L., Campitelli M.A., Chung H., Crowcroft N. S. , Karnauchow T., Katz K., Ko D. T., McGeer A. J., McNally D., Richardson D.  C.,  Rosella  L.  C.,  Simor  A.,  Smieja  M.,  Zahariadis G.,  Gubbay  J.  B.  Acute  myocardial  infarction  after laboratory-confirmed  influenza  infection.  The  New England  Journal  of  Medicine.  2018;378(26):2538-41. doi:10.1056/NEJMoa1702090.</mixed-citation>
     <mixed-citation xml:lang="en">Kwong J. C. , Schwartz K. L., Campitelli M.A., Chung H., Crowcroft N. S. , Karnauchow T., Katz K., Ko D. T., McGeer A. J., McNally D., Richardson D.  C.,  Rosella  L.  C.,  Simor  A.,  Smieja  M.,  Zahariadis G.,  Gubbay  J.  B.  Acute  myocardial  infarction  after laboratory-confirmed  influenza  infection.  The  New England  Journal  of  Medicine.  2018;378(26):2538-41. doi:10.1056/NEJMoa1702090.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Smeeth L., Thomas S. L., Hall A. J., Hubbard R., Farrington P. Vallance P. Risk of myocardial infarction and stroke after acute infection or vaccination. The New England  Journal  of  Medicine.2004;351(25):2611-8. doi:10.1056/NEJMoa041747.</mixed-citation>
     <mixed-citation xml:lang="en">Smeeth L., Thomas S. L., Hall A. J., Hubbard R., Farrington P. Vallance P. Risk of myocardial infarction and stroke after acute infection or vaccination. The New England  Journal  of  Medicine.2004;351(25):2611-8. doi:10.1056/NEJMoa041747.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Driggin  E.,  Madhavan  M.  V.,  Bikdeli  B., Chuich  T.,  Laracy  J.,  Biondi-Zoccai  G.,  Brown  T.S., Nigoghossian C. D., Zidar D. A., Haythe J., Brodie D., Beckman J. A, Kirtane A. J., Stone G. W., Krumholz H. M., Parikh S. A. Cardiovascular considerations for patients,  health  care  workers,  and  health  systems during  the  coronavirus  disease  2019  (COVID-19) pandemic.  Journal  of  the  American  College  of Cardiology.  2020;75(18):2352-2371.  doi:10.1016/j. jacc.2020.03.031.</mixed-citation>
     <mixed-citation xml:lang="en">Driggin  E.,  Madhavan  M.  V.,  Bikdeli  B., Chuich  T.,  Laracy  J.,  Biondi-Zoccai  G.,  Brown  T.S., Nigoghossian C. D., Zidar D. A., Haythe J., Brodie D., Beckman J. A, Kirtane A. J., Stone G. W., Krumholz H. M., Parikh S. A. Cardiovascular considerations for patients,  health  care  workers,  and  health  systems during  the  coronavirus  disease  2019  (COVID-19) pandemic.  Journal  of  the  American  College  of Cardiology.  2020;75(18):2352-2371.  doi:10.1016/j. jacc.2020.03.031.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Tang N., Li D., Wang X., Sun Z. Abnormal coagulation  parameters  are  associated  with  poor prognosis  in  patients  with  novel  coronavirus pneumonia. Journal of Thrombosis and Haemostasis 2020; 1-4. doi:10.1111/jth.14768.</mixed-citation>
     <mixed-citation xml:lang="en">Tang N., Li D., Wang X., Sun Z. Abnormal coagulation  parameters  are  associated  with  poor prognosis  in  patients  with  novel  coronavirus pneumonia. Journal of Thrombosis and Haemostasis 2020; 1-4. doi:10.1111/jth.14768.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hu H., Ma F., Wei X., Fang Y. Coronavirus fulminant myocarditis saved with glucocorticoid and human  immunoglobulin  Hongde.  European  Heart Journal. 2020;1307800. doi:10.1093/eurheartj/ehaa190.</mixed-citation>
     <mixed-citation xml:lang="en">Hu H., Ma F., Wei X., Fang Y. Coronavirus fulminant myocarditis saved with glucocorticoid and human  immunoglobulin  Hongde.  European  Heart Journal. 2020;1307800. doi:10.1093/eurheartj/ehaa190.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chen C., Zhou Y., Wen Wang D. SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz. 2020;10-2. doi:10.1007/s00059-020-04909-z.</mixed-citation>
     <mixed-citation xml:lang="en">Chen C., Zhou Y., Wen Wang D. SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz. 2020;10-2. doi:10.1007/s00059-020-04909-z.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zeng J.H., Liu Y., Yuan J., Wang F., Wu W., Li J., Wang L., Gao H., Wang Y., Dong C., Li Y., Xie X., Feng C., Liu L. First case of COVID-19 infection with fulminant myocarditis complication: case report and insights.  Infection.2020;10:1-5.  doi:  10.1007/s15010- 020-01424-5.</mixed-citation>
     <mixed-citation xml:lang="en">Zeng J.H., Liu Y., Yuan J., Wang F., Wu W., Li J., Wang L., Gao H., Wang Y., Dong C., Li Y., Xie X., Feng C., Liu L. First case of COVID-19 infection with fulminant myocarditis complication: case report and insights.  Infection.2020;10:1-5.  doi:  10.1007/s15010- 020-01424-5.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Luo W., Yu H., Gou J., Li X., Sun Y., Li J. Clinical pathology of critical patient with coronavirus pneumonia (COVID-19). Pre- Prints. 2020;1-14.</mixed-citation>
     <mixed-citation xml:lang="en">Luo W., Yu H., Gou J., Li X., Sun Y., Li J. Clinical pathology of critical patient with coronavirus pneumonia (COVID-19). Pre- Prints. 2020;1-14.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Xu  X.,  Gao  X.  Immunological  responses against  SARS-coronavirus  infection  in  humans. Cellular &amp; Molecular Immunology. 2004;1(2):119-22.</mixed-citation>
     <mixed-citation xml:lang="en">Xu  X.,  Gao  X.  Immunological  responses against  SARS-coronavirus  infection  in  humans. Cellular &amp; Molecular Immunology. 2004;1(2):119-22.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Wang Y.D., Sin Wan-Yee Fion, Xu Guo-Bing, Yang Huang-Hua, Yong X. T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS. Journal of Virology. 2004;78(14):7861.  doi:10.1128/JVI.78.11.5612-5618.</mixed-citation>
     <mixed-citation xml:lang="en">Wang Y.D., Sin Wan-Yee Fion, Xu Guo-Bing, Yang Huang-Hua, Yong X. T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS. Journal of Virology. 2004;78(14):7861.  doi:10.1128/JVI.78.11.5612-5618.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Alhogbani  T.  Acute  myocarditis  associated with  novel  Middle  East  respiratory  syndrome coronavirus. Annals of Saudi Medicine. 2016;36(1):78- 80. doi:10.5144/0256-4947.2016.78.</mixed-citation>
     <mixed-citation xml:lang="en">Alhogbani  T.  Acute  myocarditis  associated with  novel  Middle  East  respiratory  syndrome coronavirus. Annals of Saudi Medicine. 2016;36(1):78- 80. doi:10.5144/0256-4947.2016.78.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ruan Q., Yang K., Wang W., Jiang L., Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Medicine. 2020; 46(5):846-848. doi:10.1007/s00134-020-05991-x.</mixed-citation>
     <mixed-citation xml:lang="en">Ruan Q., Yang K., Wang W., Jiang L., Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Medicine. 2020; 46(5):846-848. doi:10.1007/s00134-020-05991-x.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Mehta P., McAuley D. F., Brown M., Sanchez E.,  Tattersall  R.  S.,  Manson  J.  J.  Correspondence COVID-19: consider cytokine storm syndromes and immunosuppression.  Lancet.  2020;6736(20):19-20. doi:10.1016/S0140-6736(20)30628-0.</mixed-citation>
     <mixed-citation xml:lang="en">Mehta P., McAuley D. F., Brown M., Sanchez E.,  Tattersall  R.  S.,  Manson  J.  J.  Correspondence COVID-19: consider cytokine storm syndromes and immunosuppression.  Lancet.  2020;6736(20):19-20. doi:10.1016/S0140-6736(20)30628-0.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chen G., Wu D., Guo W., Cao Y., Huang D., Wang H., Zhang X., Chen H., Yu H., Zhang X., Zhang M., Wu S., Song J., Chen T., Han M., Li S., Luo X., Zhao J., Ning Q. Clinical and immunologic features in severe and  moderate  forms  of  coronavirus  disease  2019. Journal of Clinical Investigation.2020; 1;130 (5):2620- 2629. doi:10.1172/JCI137244.</mixed-citation>
     <mixed-citation xml:lang="en">Chen G., Wu D., Guo W., Cao Y., Huang D., Wang H., Zhang X., Chen H., Yu H., Zhang X., Zhang M., Wu S., Song J., Chen T., Han M., Li S., Luo X., Zhao J., Ning Q. Clinical and immunologic features in severe and  moderate  forms  of  coronavirus  disease  2019. Journal of Clinical Investigation.2020; 1;130 (5):2620- 2629. doi:10.1172/JCI137244.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Alvi R.M., Frigault M. J., Fradley M. G., Jain M. D., Mahmood S. S., Awadalla M., Lee D. H., Zlotoff D. A., Zhang L., Drobni Z. D., Malek Z. O., Bassily E., Isaac  R.,  Ismail-Khan  R.,  Mulligan  C.  P.,  Banerji  D., Lazaryan A., Shah B. D., Rokicki A., Raje N., Chavez J. C., Abramson J., Locke  F.  L. Cardiovascular events among adults treated with chimeric antigen receptor T-cells (CAR-T). Journal of the American College of Cardiology.  2019;74(25):3099-108.  doi:10.1016/j. jacc.2019.10.038.</mixed-citation>
     <mixed-citation xml:lang="en">Alvi R.M., Frigault M. J., Fradley M. G., Jain M. D., Mahmood S. S., Awadalla M., Lee D. H., Zlotoff D. A., Zhang L., Drobni Z. D., Malek Z. O., Bassily E., Isaac  R.,  Ismail-Khan  R.,  Mulligan  C.  P.,  Banerji  D., Lazaryan A., Shah B. D., Rokicki A., Raje N., Chavez J. C., Abramson J., Locke  F.  L. Cardiovascular events among adults treated with chimeric antigen receptor T-cells (CAR-T). Journal of the American College of Cardiology.  2019;74(25):3099-108.  doi:10.1016/j. jacc.2019.10.038.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B24">
    <label>24.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Z., Xiong Y., Zhao Y., Li Y., Wang X., Peng Z. Clinical characteristics of  138  hospitalized  patients  with  2019  novel coronavirus-infected  pneumonia  in  Wuhan,  China. JAMA.2020;7;323(11):1061-1069.  doi:10.1001/ jama.2020.1585.</mixed-citation>
     <mixed-citation xml:lang="en">Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Z., Xiong Y., Zhao Y., Li Y., Wang X., Peng Z. Clinical characteristics of  138  hospitalized  patients  with  2019  novel coronavirus-infected  pneumonia  in  Wuhan,  China. JAMA.2020;7;323(11):1061-1069.  doi:10.1001/ jama.2020.1585.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B25">
    <label>25.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Jing-Wei Li, Han Tian-Wen, Woodward M., Anderson C. S., Zhou H., Chen Yun-Dai, Neal B. The impact  of  2019  novel  coronavirus  on  heart  injury: A  Systematicreview  and  Meta-analysis.  Progress in  Cardiovascular  Diseases.  2020;  16;S0033-0620 (20)30080-3. doi:10.1016 / j. pcad.2020.04.008.</mixed-citation>
     <mixed-citation xml:lang="en">Jing-Wei Li, Han Tian-Wen, Woodward M., Anderson C. S., Zhou H., Chen Yun-Dai, Neal B. The impact  of  2019  novel  coronavirus  on  heart  injury: A  Systematicreview  and  Meta-analysis.  Progress in  Cardiovascular  Diseases.  2020;  16;S0033-0620 (20)30080-3. doi:10.1016 / j. pcad.2020.04.008.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B26">
    <label>26.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ying-Ying  Zheng,  Ma  Yi-Tong,  Jin-Ying Zhang,  Xie  X.  COVID-19  and  the  cardiovascular system.  Nature  Reviews  Cardiology.  2020;17(5):259- 260. doi: 10.1038/s41569-020-0360-5</mixed-citation>
     <mixed-citation xml:lang="en">Ying-Ying  Zheng,  Ma  Yi-Tong,  Jin-Ying Zhang,  Xie  X.  COVID-19  and  the  cardiovascular system.  Nature  Reviews  Cardiology.  2020;17(5):259- 260. doi: 10.1038/s41569-020-0360-5</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B27">
    <label>27.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Adriano N.C., Tagliari A. P., Forleo G. B., Fassini  G.  M.,  Tondo  C.  Cardiac  and  arrhythmic complications in patients with COVID-19 Journal of Cardiovascular  Electrophysiology.  2020;31  (5):1003- 1008. doi: 10.1111/jce.14479.</mixed-citation>
     <mixed-citation xml:lang="en">Adriano N.C., Tagliari A. P., Forleo G. B., Fassini  G.  M.,  Tondo  C.  Cardiac  and  arrhythmic complications in patients with COVID-19 Journal of Cardiovascular  Electrophysiology.  2020;31  (5):1003- 1008. doi: 10.1111/jce.14479.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B28">
    <label>28.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yang X., Xu J., Shu H., Xia J., Liu H., Wu Y., Zhang L., Yu Z., Fang M., Yu T., Wang Y., Pan S., Zou X.,  Yuan  S.,  Shang  Y.  Clinical  course  and  outcomes of critically ill patients with SARS-CoV-2 pneumonia in  Wuhan,  China:  a  single-centered,  retrospective, observational  study.  The  Lancet  Respiratory Medicine.  2020;8(5):475-481.  doi:  10.1016/S2213- 2600(20)30079-5.</mixed-citation>
     <mixed-citation xml:lang="en">Yang X., Xu J., Shu H., Xia J., Liu H., Wu Y., Zhang L., Yu Z., Fang M., Yu T., Wang Y., Pan S., Zou X.,  Yuan  S.,  Shang  Y.  Clinical  course  and  outcomes of critically ill patients with SARS-CoV-2 pneumonia in  Wuhan,  China:  a  single-centered,  retrospective, observational  study.  The  Lancet  Respiratory Medicine.  2020;8(5):475-481.  doi:  10.1016/S2213- 2600(20)30079-5.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B29">
    <label>29.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">He X.W., Lai J. S., Cheng J., Wang M. W., Liu Y. J., Xiao Z. C., Xu C., Li S. S., Zeng H. S. Impact of complicated myocardial injury on the  clinical outcome of severe or critically ill COVID-19 patients. Zhonghua Xin  Xue  Guan  Bing  Za  Zhi  2020;48,E011.  doi:  10.3760/cma.j.cn112148-20200228-00137.</mixed-citation>
     <mixed-citation xml:lang="en">He X.W., Lai J. S., Cheng J., Wang M. W., Liu Y. J., Xiao Z. C., Xu C., Li S. S., Zeng H. S. Impact of complicated myocardial injury on the  clinical outcome of severe or critically ill COVID-19 patients. Zhonghua Xin  Xue  Guan  Bing  Za  Zhi  2020;48,E011.  doi:  10.3760/cma.j.cn112148-20200228-00137.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B30">
    <label>30.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., Xiang J., Wang Y., Song B., Gu X., Guan L., Wei Y., Li H., Wu X., Xu J., Tu S., Zhang Y., Chen H., Cao B. Clinical course and risk factors for mortality of adult inpatients with  COVID-19  in  Wuhan,  China:  a  retrospective cohort study. The Lancet 2020;395(10229):1054-1062. doi:10.1016/S0140-6736(20)30566-3.</mixed-citation>
     <mixed-citation xml:lang="en">Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., Xiang J., Wang Y., Song B., Gu X., Guan L., Wei Y., Li H., Wu X., Xu J., Tu S., Zhang Y., Chen H., Cao B. Clinical course and risk factors for mortality of adult inpatients with  COVID-19  in  Wuhan,  China:  a  retrospective cohort study. The Lancet 2020;395(10229):1054-1062. doi:10.1016/S0140-6736(20)30566-3.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B31">
    <label>31.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Fu L., Fei J., Xiang Hui-Xian, Xiang Y., Tan Zhu-Xia , Li Meng-Die, Liu Fang-Fang, Liu Hong- Yan, Zheng L., Li Y. Influence factors of death risk among  COVID-19  patients  in  Wuhan,  China:  a hospital-based case-cohort study. MedRxiv.2020. doi: 10.1101/2020.03.13.20035329</mixed-citation>
     <mixed-citation xml:lang="en">Fu L., Fei J., Xiang Hui-Xian, Xiang Y., Tan Zhu-Xia , Li Meng-Die, Liu Fang-Fang, Liu Hong- Yan, Zheng L., Li Y. Influence factors of death risk among  COVID-19  patients  in  Wuhan,  China:  a hospital-based case-cohort study. MedRxiv.2020. doi: 10.1101/2020.03.13.20035329</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B32">
    <label>32.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chen T., Wu D., Chen H., Yan W., Yang D., Chen G., Ma K., Xu D., Yu H., Wang H., Wang T., Guo  W.,  Chen  J.,  Ding  C.,  Clinical  characteristics of  113  deceased  patients  with  coronavirus  disease 2019: retrospective study. BMJ. 2020;368:m1091. doi: 10.1136/bmj.m1091.</mixed-citation>
     <mixed-citation xml:lang="en">Chen T., Wu D., Chen H., Yan W., Yang D., Chen G., Ma K., Xu D., Yu H., Wang H., Wang T., Guo  W.,  Chen  J.,  Ding  C.,  Clinical  characteristics of  113  deceased  patients  with  coronavirus  disease 2019: retrospective study. BMJ. 2020;368:m1091. doi: 10.1136/bmj.m1091.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B33">
    <label>33.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zhang F., Zhang F., Yang D., Li J., Gao P., Chen T., Cheng Z., Cheng K., Fang Q., Pan W., Fan H., Wu Y., Li L., Fang Y., Liu J., Tian G., He L. Myocardial injury is associated with in-hospital mortality of confirmed or  suspected  COVID-19  in  Wuhan,  China:  a  single center retrospective cohort study.  MedRxiv; 2020. doi: 10.1101/2020.03.21.20040121</mixed-citation>
     <mixed-citation xml:lang="en">Zhang F., Zhang F., Yang D., Li J., Gao P., Chen T., Cheng Z., Cheng K., Fang Q., Pan W., Fan H., Wu Y., Li L., Fang Y., Liu J., Tian G., He L. Myocardial injury is associated with in-hospital mortality of confirmed or  suspected  COVID-19  in  Wuhan,  China:  a  single center retrospective cohort study.  MedRxiv; 2020. doi: 10.1101/2020.03.21.20040121</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B34">
    <label>34.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Liu  Y.,  Li  J.,  Liu  D.,  Song  H.,  Chen  C. Clinical  features  and  outcomes  of  2019  novel coronavirusinfected  patients  with  cardiac  injury. MedRxiv; 2020. doi:10.1101/2020.03.11.20030957</mixed-citation>
     <mixed-citation xml:lang="en">Liu  Y.,  Li  J.,  Liu  D.,  Song  H.,  Chen  C. Clinical  features  and  outcomes  of  2019  novel coronavirusinfected  patients  with  cardiac  injury. MedRxiv; 2020. doi:10.1101/2020.03.11.20030957</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B35">
    <label>35.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Guo  T.,  Fan  Y.,  Chen  M.,  Wu  X.,  Zhang L.,  He  T.,  Wang  H.,  Wan  J.,  Wang  X.,  Lu  Z. Cardiovascular  implications  of  fatal  outcomes  of patients  with  coronavirus  disease  2019  (COVID-19). JAMA  Cardiology.  2020.5(7):811-818.  doi:10.1001/ jamacardio.2020.1017</mixed-citation>
     <mixed-citation xml:lang="en">Guo  T.,  Fan  Y.,  Chen  M.,  Wu  X.,  Zhang L.,  He  T.,  Wang  H.,  Wan  J.,  Wang  X.,  Lu  Z. Cardiovascular  implications  of  fatal  outcomes  of patients  with  coronavirus  disease  2019  (COVID-19). JAMA  Cardiology.  2020.5(7):811-818.  doi:10.1001/ jamacardio.2020.1017</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B36">
    <label>36.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Liu J., Zhang L., Zhu F., Xie L., Wang C., Wang J., Chen R. Clinical characteristics and treatment of patients infected with COVID-19 in Shishou, China. SSRN Pre-Print.. doi:10.2139/ssrn.3541147</mixed-citation>
     <mixed-citation xml:lang="en">Liu J., Zhang L., Zhu F., Xie L., Wang C., Wang J., Chen R. Clinical characteristics and treatment of patients infected with COVID-19 in Shishou, China. SSRN Pre-Print.. doi:10.2139/ssrn.3541147</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B37">
    <label>37.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Inciardi R.M., Lupi L., Zaccone G., Italia L., Raffo M., Tomasoni D., Cani D. S., Cerini M., Farina D., Gavazzi E., Maroldi R., Adamo M., Ammirati E.,  Sinagra  G.,  Lombardi  C.  M.,  Metra  M.  Cardiac involvement  in  a  patient  with  coronavirus  disease 2019 (COVID-19). JAMA Cardiology. 2020;5(7):1-6. doi:10.1001/jamacardio.2020.1096.</mixed-citation>
     <mixed-citation xml:lang="en">Inciardi R.M., Lupi L., Zaccone G., Italia L., Raffo M., Tomasoni D., Cani D. S., Cerini M., Farina D., Gavazzi E., Maroldi R., Adamo M., Ammirati E.,  Sinagra  G.,  Lombardi  C.  M.,  Metra  M.  Cardiac involvement  in  a  patient  with  coronavirus  disease 2019 (COVID-19). JAMA Cardiology. 2020;5(7):1-6. doi:10.1001/jamacardio.2020.1096.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B38">
    <label>38.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Stroup D.F., Berlin J. A., Morton S. C., Olkin I., Williamson G. D., Rennie D., Moher D., Becker B. J., Sipe T., Thacker A. S. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta analysis Of Observational Studies in Epidemiology (MOOSE)  group.  JAMA  2000;283:2008-2012.  doi: 10.1001/jama.283.15.2008.</mixed-citation>
     <mixed-citation xml:lang="en">Stroup D.F., Berlin J. A., Morton S. C., Olkin I., Williamson G. D., Rennie D., Moher D., Becker B. J., Sipe T., Thacker A. S. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta analysis Of Observational Studies in Epidemiology (MOOSE)  group.  JAMA  2000;283:2008-2012.  doi: 10.1001/jama.283.15.2008.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B39">
    <label>39.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Rothman K.J., Greenland S, Lash T.L. Modern epidemiology. 2nd ed. USA: Lippincott Williams &amp; Wilkins Publishers; 2008.</mixed-citation>
     <mixed-citation xml:lang="en">Rothman K.J., Greenland S, Lash T.L. Modern epidemiology. 2nd ed. USA: Lippincott Williams &amp; Wilkins Publishers; 2008.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B40">
    <label>40.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Cai  Q.,  Huang  D.,  Ou  P.  2019-nCoV pneumonia  in  a  normal  work  infectious  diseases hospital  besides  Hubei  Province,  China.  doi:10.2139/ ssrn.3542163</mixed-citation>
     <mixed-citation xml:lang="en">Cai  Q.,  Huang  D.,  Ou  P.  2019-nCoV pneumonia  in  a  normal  work  infectious  diseases hospital  besides  Hubei  Province,  China.  doi:10.2139/ ssrn.3542163</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B41">
    <label>41.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Lu H., Lu H., Ai J., Shen Y., Li Y., Li T., Zhou X., Zhang H. Zhang Q. Ling Y., Wang S., Qu H., Gao Y., Li Y., Zhu D., Zhu H., Tian R., Zeng M. A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2  outbreak  in  Shanghai,  lessons  learned formetropolis epidemics prevention. MedRxiv Pre- Print; 2020. doi:10.1101/2020.02.19.20025031.</mixed-citation>
     <mixed-citation xml:lang="en">Lu H., Lu H., Ai J., Shen Y., Li Y., Li T., Zhou X., Zhang H. Zhang Q. Ling Y., Wang S., Qu H., Gao Y., Li Y., Zhu D., Zhu H., Tian R., Zeng M. A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2  outbreak  in  Shanghai,  lessons  learned formetropolis epidemics prevention. MedRxiv Pre- Print; 2020. doi:10.1101/2020.02.19.20025031.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B42">
    <label>42.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Shi S., Qin M., Shen B., Cai Y., Liu T., Yang F., Gong W., Liu X., Liang J., Zhao Q., Huang H., Yang B., Huang C. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China.  JAMA.  2020.25;5(7):802-810.  doi:  10.1001/ jamacardio.2020.0950</mixed-citation>
     <mixed-citation xml:lang="en">Shi S., Qin M., Shen B., Cai Y., Liu T., Yang F., Gong W., Liu X., Liang J., Zhao Q., Huang H., Yang B., Huang C. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China.  JAMA.  2020.25;5(7):802-810.  doi:  10.1001/ jamacardio.2020.0950</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B43">
    <label>43.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zheng Y-Y., Ma Yi-Tong, Zhang Jin-Ying, Xie X. COVID-19 and the cardiovascular system. Nature Reviews  Cardiology.  2020.  17  (5):  1-2  doi:  10.1038/ s41569-020-0360-5.</mixed-citation>
     <mixed-citation xml:lang="en">Zheng Y-Y., Ma Yi-Tong, Zhang Jin-Ying, Xie X. COVID-19 and the cardiovascular system. Nature Reviews  Cardiology.  2020.  17  (5):  1-2  doi:  10.1038/ s41569-020-0360-5.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B44">
    <label>44.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kulanthaivel  S.,  Kaliberdenko  V.B., Balasundaram  K.,  Shterenshis  M.V.,  Scarpellini  E., Abenavoli  L.  Tocilizumab  in  SARS-COV-2  Patients with the Syndrome of Cytokine Storm; a Narrative review. Reviews on Recent Clinical Trials. 2020 Sep 17. Epub ahead of print. doi:10.2174/15748871156662009 17110954. PMID.</mixed-citation>
     <mixed-citation xml:lang="en">Kulanthaivel  S.,  Kaliberdenko  V.B., Balasundaram  K.,  Shterenshis  M.V.,  Scarpellini  E., Abenavoli  L.  Tocilizumab  in  SARS-COV-2  Patients with the Syndrome of Cytokine Storm; a Narrative review. Reviews on Recent Clinical Trials. 2020 Sep 17. Epub ahead of print. doi:10.2174/15748871156662009 17110954. PMID.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B45">
    <label>45.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Wu Z., McGoogan J. M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;2019:3- 6.</mixed-citation>
     <mixed-citation xml:lang="en">Wu Z., McGoogan J. M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;2019:3- 6.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
