Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry Ученые записки Крымского федерального университета имени В.И. Вернадского. Биология. Химия. 2413-1725 100973 10.29039/2413-1725-2025-11-2-265-280 БИОЛОГИЧЕСКИЕ НАУКИ BIOLOGICAL SCIENCES БИОЛОГИЧЕСКИЕ НАУКИ CHANGES IN MOTOR ACTIVITY AND ANXIETY LEVELS OF RATS OF DIFFERENT AGES UPON BLOCKING MONOAMINE OXIDASE-B ИЗМЕНЕНИЯ ДВИГАТЕЛЬНОЙ АКТИВНОСТИ И УРОВНЯ ТРЕВОЖНОСТИ КРЫС РАЗНОГО ВОЗРАСТА ПРИ БЛОКИРОВАНИИ МОНОАМИНОКСИДАЗЫ-В Хусаинов Д. Р. Husainov D. R. Аидинов И. Д. Aidinov I. D. Туманянц К. Н. Tumanyanc K. N. Семыкин В. А.. Semykin V. A.. Крымский федеральный университет имени В.И.Вернадского Crimean Federal University of a name of V.I.Vernadsky 04 07 2025 04 07 2025 11 2 265 280 04 07 2025 https://sn-biolchem.cfuv.ru/изменения-двигательной-активности-и/

Предполагается, что в процессе старения подавление дофаминергической системы наблюдается и без выраженных патологических проявлений, но этот вопрос остается дискуссионным и особенно неоднозначно оценивается роль центрального дофамина в старческом увеличении уровня тревожности. В связи с отмеченным в настоящем исследовании определялись изменения двигательной активности и уровня тревожности крыс возрастом 7 месяцев, 12 и 24 месяца в условиях блокады моноаминоксидазы-В. При блокировании моноаминоксидазы-В и увеличении содержания центрального дофамина, получен однозначный результат, что с возрастом его значимость в контроле уровня тревожности снижается, что, вероятно, приводит к падению стрессоустойчивости и увеличению уровня тревожности и этот феномен проявляется уже при 12-ти месячном возрасте крыс.

With age, there is a gradual decrease in motor activity in humans [1] and animals [2]. This is based on a whole list of natural causes: functional deterioration of blood circulation especially in the microcirculatory channel, decreased mobility of joints, decreased level of metabolic processes other age-related changes [3], hypodynamia and hypokinesia [4], senile loneliness [5] increase their influence. One of the most important factors of age-related suppression of motor activity is not only a decrease in the functional capabilities of muscles, but also in the plasticity and general functional capabilities of the central nervous system and its peripheral departments [6, 7]. Psychoemotional, cognitive age-related changes and disorders are essential [8]. It should be noted that age-related changes are characterised by a decrease in stress tolerance, an increase in anxiety and worry, and the development of prodepressive manifestations [3]. The dopaminergic system is of significant importance in all the above changes [9, 10]. Undeniable suppression of the activity of the dopaminergic system is shown in senile dementia, Parkinson’s disease [11] in a number of other diseases [10]. The question of involvement of the dopaminergic system in senile changes remains debatable and the role of monoamine oxidase and central dopamine [12, 13], including in the age-related increase in the anxiety level of a conditionally healthy person, is particularly ambiguous. In connection with the above-mentioned, the following objective was set in the present study: to determine the changes in motor activity and anxiety level in 7-month-old, 12-month-old and 24-month-old rats when MAO-B was blocked.

 двигательная активность индекс тревожности моноаминоксидаза дофамин возрастные изменения. motor activity anxiety index monoamine oxidase dopamine age-related changes

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