Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry Ученые записки Крымского федерального университета имени В.И. Вернадского. Биология. Химия. 2413-1725 91883 10.29039/2413-1725-2024-10-3-274-282 БИОЛОГИЧЕСКИЕ НАУКИ BIOLOGICAL SCIENCES БИОЛОГИЧЕСКИЕ НАУКИ GLUCOCORTICOID ACTIVITY OF THE ADRENAL CORTEX IN THE BODY OF HIGHLY QUALIFIED ATHLETES WITH DIFFERENT LEVELS OF FUNCTIONING OF THE REPRODUCTIVE SYSTEM ГЛЮКОКОРТИКОИДНАЯ АКТИВНОСТЬ КОРЫ НАДПОЧЕЧНИКОВ В ОРГАНИЗМЕ ВЫСОКОКВАЛИФИЦИРОВАННЫХ СПОРТСМЕНОК С РАЗЛИЧНЫМ УРОВНЕМ ФУНКЦИОНИРОВАНИЯ РЕПРОДУКТИВНОЙ СИСТЕМЫ Юферев В. С. Yuferev V. S. Погодина С. В. Pogodina S. V. Крымский федеральный университет имени В.И.Вернадского Crimean Federal University of a name of V.I.Vernadsky 12 12 2024 12 12 2024 10 3 274 282 12 12 2024 https://sn-biolchem.cfuv.ru/glyukokortikoidnaya-aktivnost-kory-nadpochechnikov-v-organizme-vysokokvalificzirovannyh-sportsmenok-s-razlichnym-urovnem-funkczionirovaniya-reproduktivnoj-sistemy/

Обследованы спортсменки со средней продолжительностью менструального цикла 28–30 дней 37–45 и 16–26 лет. Проведены иммуноферментный анализ содержания гонадотропных и половых гормонов, иммунохроматографический in vitro тест на овуляцию, статистический анализ данных. У спортсменок с ановуляторным менструальным циклом диапазон глюкокортикоидной реакции на пороговые физические нагрузки сужается, что ограничивает их компенсаторно-приспособительные возможности. Прием орального противозачаточного препарата Мерсилон обусловливает повышение глюкокортикоидной активности, выходящей за пределы нормальных значений, что является компенсаторно-приспособительной реакцией в системе стероидогенеза.

Athletes with an average menstrual cycle duration of 28-30 days, 37-45 and 16-26 years old were examined. Enzyme immunoassay of gonadotropin and sex hormones, immunochromatographic in vitro ovulation test, and statistical data analysis were performed. In athletes with an anovulatory menstrual cycle, the range of glucocorticoid response to threshold physical activity narrows, which limits their compensatory and adaptive capabilities. Taking the oral contraceptive drug Mercilon causes an increase in glucocorticoid activity beyond normal values, which is a compensatory adaptive reaction in the steroidogenesis system. In the body of highly skilled athletes in the dynamics of ovarian and menstrual anovulatory menstrual cycle set gipoergicheskom glucocorticoid response. Range is expressed glucocorticoid response characteristics depending on the level of functioning of the reproductive system. The dynamics of the ovulatory menstrual cycle shows a relatively wide range of glucocorticoid response, thus increasing the level of compensatory and adaptive capabilities steroidogenesis system in the troubled periods of the menstrual cycle. In athletes with anovulatory menstrual cycle glucocorticoid response range is narrow, which limits the compensatory-adaptive possibilities. Admission Mersilon contraceptive drug has an effect on the range of glucocorticoid response, which is the estimated ovulation period exceeds the range of its normal physiological fluctuations. In the body of highly qualified athletes, in the dynamics of OMC and AMC, when performing threshold loads, mainly hypoallergenic glucocorticoid reactions were established, which is associated with a decrease in the reactivity of the adrenal cortex to threshold loads. Hyperergic glucocorticoid reactions were detected with a decrease in estrogen saturation and are compensatory and adaptive in the steroidogenesis system. A drop in estrogen saturation below normal values increases the degree of adaptive stress at the level of the glucocorticoid and ventilator links of the stress reaction. A relatively wide range of glucocorticoid reactions has been established in the dynamics of the OMC, which has a high sensitivity to hormonal regulatory influences at the level of the average threshold power of work.

 глюкокортикоидная активность диапазон реакции спортсменки женщины физические нагрузки особенности репродуктивной функции ановуляторный менструальный цикл контрацептивы glucocorticoid activity reactions range athletes women physical activity especially reproductive function anovulatory menstrual cycle contraceptive

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