With age, there is a gradual decrease in motor activity in humans [1] and animals [2]. This is based on a whole list of natural causes: functional deterioration of blood circulation especially in the microcirculatory channel, decreased mobility of joints, decreased level of metabolic processes other age-related changes [3], hypodynamia and hypokinesia [4], senile loneliness [5] increase their influence. One of the most important factors of age-related suppression of motor activity is not only a decrease in the functional capabilities of muscles, but also in the plasticity and general functional capabilities of the central nervous system and its peripheral departments [6, 7]. Psychoemotional, cognitive age-related changes and disorders are essential [8]. It should be noted that age-related changes are characterised by a decrease in stress tolerance, an increase in anxiety and worry, and the development of prodepressive manifestations [3]. The dopaminergic system is of significant importance in all the above changes [9, 10]. Undeniable suppression of the activity of the dopaminergic system is shown in senile dementia, Parkinson’s disease [11] in a number of other diseases [10]. The question of involvement of the dopaminergic system in senile changes remains debatable and the role of monoamine oxidase and central dopamine [12, 13], including in the age-related increase in the anxiety level of a conditionally healthy person, is particularly ambiguous. In connection with the above-mentioned, the following objective was set in the present study: to determine the changes in motor activity and anxiety level in 7-month-old, 12-month-old and 24-month-old rats when MAO-B was blocked.
motor activity, anxiety index, monoamine oxidase, dopamine, age-related changes
1. Gerstorf D. Today's Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past. / Gerstorf D., Ram N., Drewelies J., Duezel S. [et al.]
2. Graber T. G. Measuring Exercise Capacity and Physical Function in Adult and Older Mice. / Graber T. G., Maroto R., Fry C. S., Brightwell C. R., Rasmussen B. B. // J Gerontol A Biol Sci Med Sci. – 2021
3. Pristrom M. S. Starenie fiziologicheskoe i prezhdevremennoe. Sovremennyy vzglyad na problemu. / Pristrom M. S., Pristrom S. L., Semenenkov I. I. // Mezhdunarodnye obzory
4. Kuznecova Z. M. Dvigatel'naya aktivnost' kak sredstvo profilaktiki vozrastnyh izmeneniy / Kuznecova Z. M., Maksimova E. F. // Pedagogiko-psihologicheskie i mediko-biologicheskie
5. Buchman A. S. Loneliness and the rate of motor decline in old age: the rush memory and aging project, a community-based cohort study. / Buchman A. S., Boyle P. A., Wilson R. S. et al. // BMC Geriatr – 2010. – 10.
6. Wrucke D. J. Neural and muscular contributions to the age-related differences in peak power of the knee extensors in men and women. / Wrucke D. J., Kuplic A., Adam M. D., Hunter S. K., Sundberg C. W.
7. Guo Y. Sex disparities of human neuromuscular decline in older humans. / Guo Y., Jones E. J., Smart T. F. [et al.] // J Physiol. – 2025 – 603(1) – R. 151–165. doi:https://doi.org/10.1113/JP285653. Epub 2024 Jun
8. Gonzalez M. C. Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia. / Gonzalez M. C., Tovar-Rios D. A., Alves G. [et al.] // Mov Disord Clin Pract. – 2023 – 10(6) – R. 980
9. Sagheddu C. Cognitive performance in aged rats is associated with differences in distinctive neuronal populations in the ventral tegmental area and altered synaptic plasticity in the hippocampus. / Sagheddu
10. Sanfeliu C. New insights in animal models of neurotoxicity-induced neurodegeneration. / Sanfeliu C., Bartra C., Susol C., Rodrnguez-Farry E. // Front Neurosci. – 2024 – 17 – 1248727.
11. Soto I. Aging accelerates locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. / Soto I., McManus R., Navarrete W. [et al.]
12. Tbbi T. Selegiline: a molecule with innovative potential. / Tbbi T., Vycsei L., Youdim M.B., Riederer P., Szckő Y. // J Neural Transm (Vienna). – 2020. – 127(5). – R. 831–842.
13. Rossano F. Efficacy and safety of selegiline across different psychiatric disorders: A systematic review and meta-analysis of oral and transdermal formulations. / Rossano F., Caiazza C., Sobrino A., Solini N. [et al.]
14. Borbe H. O. Kinetic evaluation of MAO-B-activity following oral administration of selegiline and desmethyl-selegiline in the rat / Borbe H. O., Niebch G., Nickel B. // Journal of Neural Transmission / Amine
15. Izmenenie indeksa depressivnosti u nizko-,srednei vysokodepressivnyh krys v zavisimosti ot dlitel'nosti blokady monoaminoksidazy-V/D. R. Husainov, K. N. Tumanyanc,I. D. Aidinov,V. R.Ivanova
16. Gao X. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants. / Gao X., Geng T., Jiang M., Huang N., Zheng Y., Belsky D. W., Huang T. // Nat
17. Participation of dopaminergic system in the dynamics of behavioral reactions of aging rats of both sexes under daily testing in the open field / E. Birukova, D. Khusainov, A. Chajka [et al.] // BIO Web of
18. Srifuengfung M. Perioperative Anxiety and Depression in Older Adults: Epidemiology and Treatment. /Srifuengfung M., Abraham J., Avidan M. S., Lenze E. J//Am J Geriatr Psychiatry. – 2023 – 31(11)– R. 996-1008.
