Since itscommercial development, theuseofmoderne-cigaretteshascontinued togrowamongpeoplewho haveneversmoked, formersmokerswhohaveswitchedtoe-cigarettes,andusersofbothconventional cigarettes ande-cigarettes.Withthisincreaseinusecomesgrowingknowledgeoftheirritant, toxic,and potentiallycarcinogenic effectsonthelungs.Thesubstancesinhaledine-cigarettescontainavarietyofsubstances, includingadditivessuch asvegetableglycerinandpropyleneglycol, aswell as avorings, nicotine, andvitaminEacetate.Whenheated, glycerinandpropyleneglycol formavaporandactascarriersofnicotineand avorings.Thekeyriskfactorforvaping relatedrespiratoryillnessesistheuseofe-cigarettesorsimilarproducts.However,thepathogenesisofsuchillnesses remainsunclear.Manydifferentpathological ndingshavebeenreportedassociatedwithsuchdiseases, including acutelunginjury, diffuse alveolar injury, diffuse alveolar hemorrhage, organi ing pneumonia, acuteeosinophilicpneumonia, lipoidpneumonia, andrespiratorybronchiolitic interstitial lungdisease. Inaddition, it hasbeenmentioned that lipopolysaccharidemaycausevaping-relateddisease. Inthisreview,wesearchedscienti cdatabasessuchas Cyberleninka,RINTSDatabase, ubMed,Cochrane,Lancet inRussianandEnglishfortheperiodfrom2019 to2024. Afterreviewingtheliterature,weidenti edanewroleforthemaincomponentofthee-cigarette-glycerol inenhancing endotoxin-inducedinjurythroughactivationofneutrophilchemotaxisand brosis.Thiseffect ismediatedbyincreased expressionofadhesionmolecules and brogenesis.Theseresultsprovideimportantevidencethatthiscomponentof thee-cigarettehasaspeci cpro-in ammatoryeffect.Correspondingauthorcontact information:MaryanenkoSo ia avlovna, rst-year resident inthespecialty«Therapy ;OrdenTrudovogoKrasnogo nameniMeditsinskiyinstitute namedS.I.GeorgievskyofVernadskjyCFU.
e-cigarette,acutelunginjury,vegetableglycerin, li o olysaccharide,va ing
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