Institut biomedicinskih issledovaniy VNC RAN
Institut biomedicinskih issledovaniy VNC RAN
The aim of this study was to investigate the effects of antimony intoxicationon systemic hemodynamic parameters in rats against the background of hypercalcemia and melatonin administration. Material and methods. The experiment was conducted on 75 male Wistar rats divided into 7 groups. Over 30days, the animals were administered antimony chloride (3 mg/kg), vitamin D3 (3000 IU/100 g), and melatonin (10 mg/kg) both individually and in combination.Hypercalcemia was induced using vitamin D3. Key hemodynamic parameters, such as mean arterial pressure (MAP), heart rate (HR), cardiac index (CI), stroke index (SI), and total peripheral resistance (TPR), were measured using invasive methods. Results. The results showed that antimony intoxication caused a signifcant increase in MAP and TPR, as well as a decrease in CI and SI, indicating the development of a hypokinetic type of circulation. The administration of melatonin and vitamin D3 individually mitigated the toxic effects of antimony, reducing hypertensive effects and improving cardiac function. However, the most pronounced positive effect was observed with the combined use of melatonin and vitamin D3, which led to the normalization of MAP and signifcant restoration of cardiac function. Conclusion. The fndings confrm that melatonin and vitamin D3 can be effective in reducing the toxic effects of antimony on the cardiovascular system, particularly when used in combination. This opens prospects for further research into their protective mechanisms and potential clinical applications.
antimony, systemic hemodynamics, hypercalcemia, melatonin, vitamin D3, cardiotoxicity
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