Takotsubo Syndrome («Broken Heart Syndrome», Stress-Induced Cardiomyopathy) is a reversible, localized or diffuse myocardial lesion, more precisely, of the left ventricle (LV) and its subsequent dysfunction. The lesion is characterized by impaired systolic function, mimicking the clinical picture of acute myocardial infarction, with elevated levels of cardiac-specific enzymes in the absence of ischemia and reperfusion, resulting in the absence of myocardial necrosis markers in the blood. The most common causes are emotional and physical stress, its impact on the body. The presence of this pathology is rare, with frequent manifestation in the form of heart deformation, characterized by balloon-like dilatation of the middle part of the heart apex, hence another name for the pathology - «apical ballooning». The prognosis is favorable with timely examination and proper treatment of the disease, which is characterized by the reverse development of changes and restoration of the contractility of the heart muscle. One of the complex issues in the treatment of stress-induced cardiomyopathy is the diagnostic process, which is based on the principle of excluding possible serious pathologies of the cardiovascular and pulmonary systems of the body, having a similar symptomatic picture. This is revealed thanks to modern diagnostic methods. Based on the presented clinical observation, the authors draw attention to the issues of pathogenesis, clinical manifestations, diagnosis and treatment of a patient with apical ballooning syndrome. The clinical case is presented by a 65-year-old patient, in whom this pathology was caused by stress factors after a planned operation, which significantly simplified the diagnosis, in combination with modern diagnostic methods, it also contributed to the further restoration of the patient’s condition as a result of treatment correction.
takotsubo syndrome, stress-induced cardiomyopathy, balloon-like expansion of the middle part of the apex of the heart, broken heart syndrome, cardiomyocytes, apical ballooning syndrome.
1. Gilyarevskiy S. R. Cardiomyopathy Takotsubo. Approaches to diagnosis and treatment. Moscow: Medpress-inform; 2013. (in Russ.).
2. Matveeva M. G., Gogin G. E., Alekhin M. N. Takotsubo cardiomyopathy: case report. Clinical Medicine (Russian Journal). 2017; 95(7):663-668. doihttps://doi.org/10.18821/0023-2149- 2017-95-7-663-668 (In Russ.).
3. Boldueva S. A., Evdokimov D. S., Takotsubo cardiomyopathy. Literature review: concept, epidemiology, pathogenesis. Part I. Russian Journal of Cardiology 2022;27(3S):4993. doihttps://doi.org/10.15829/15604071-2022-4993. (In Russ.).
4. Suspitsyna I. N., Sukmanova I. A. Takotsubo syndrome. Clinical and pathogenetic aspects. Basics of diagnosis and treatment. Kardiologiia. 2020;60(2):96-103. (In Russ.). doihttps://doi.org/10.18087/cardio.2020.2.n521.
5. Latfullin I.A., Kim Z.F. Takotsubo syndrome. Cardiovascular Therapy and Prevention. 2010;9(6):109-120. (In Russ.).
6. Evdokimova A. G., Struk R. I., Evdokimov V. V., Voronina G. V., Mikhailova I. S., Golikova A. A. Takotsubo syndrome (stressinduced cardiomyopathy): case report. Cardiosomatics. 2022;13(2):107-114. doihttps://doi.org/10.17816/CS110908
7. Shilova A. S., Shmotkina A. O., Yafarova A. A., Gilyarovl M. Yu. Takotsubo Syndrome: Contemporary Views on the Pathogenesis, Prevalence and Prognosis 2020;60(2):96-103. doi:10.18087/ cardio.2020.2.n521. (In Russ.).
8. Abdrahmanova A. I., Tsibulkin N. A., Amirov N. B., Saifullina G. B., Galimzyanova L. A., Oslopova J. B. Takotsubo syndrome in the course of internal diseases. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (6): 49-
9. Litvinenko R. I, Shulenin S. N., Kulikov A. N., Nagorny M. B., Bobrov A. L., Shloido E. A., et al. The differential diagnosis of transient myocardial ischemia – takotsubo-cardiomyopathy. Vestnik Rossiiskoi Voenno-Medicinskoi
10. Alekhin M. N. Syndrome Takotsubo: the Value of the Echocardiography Kardiologiia. 2017;57(7):80-89. doihttps://doi.org/10.18087/cardio.2017.7.10009 (In Russ.).
11. Boldueva S. A., Evdokimov D.S. Takotsubo cardiomyopathy. Literature review: clinical performance, diagnostic algorithm, treatment, prognosis. Part II. Russian Journal of Cardiology. 2022;27(3S):4994. (In Russ.)
