CORNEAL COLLAGEN CROSS-LINKING – CURRENT TRENDS IN PRACTICE APPLICATIONS

A. Kopaenko; O. G. Rasin

doi:10.29039/2070-8092-2020-23-3-98-107

UDC 617

CORNEAL COLLAGEN CROSS-LINKING – CURRENT TRENDS IN PRACTICE APPLICATIONS

Published in Tavricheskiy Mediko-Biologicheskiy Vestnik · Volume 23, Issue 3 · Pages 98–107 · Rubric: Reviews

DOI: https://doi.org/10.29039/2070-8092-2020-23-3-98-107

Received: 18.10.2022 Accepted: 19.10.2022 Published: 19.10.2022 Language of publication: ru-RU

Authors

A. Kopaenko

O. G. Rasin

A. Kopaenko

V.I. Vernadsky Crimean Federal University Simferopol

O. G. Rasin

V.I. Vernadsky Crimean Federal University Simferopol

ABSTRACT

The article presents the current application of corneal collagen crosslinking. The original indication of riboflavin – Ultraviolet-A (UVA) induced corneal collagen cross-linking is to arrest the progression of keratoconus. Studies show that it is effective in arresting the progression of keratoconus and post-LASIK ectasia with the standard Dresden protocol (epithelium-off ). There are also improvements in visual, keratometric and topographic measurements over time. Severe complications of cross-linking are rare. The epithelium-on techniques have less efficacy than the Dresden protocol. Accelerated protocols have variable results, with some studies reporting comparable outcomes to the Dresden protocol while other studies reporting less efficacious outcomes. Cross- linking combined with refractive procedures provide better visual outcome but long term studies are warranted. Cross-linking for the treatment of infective keratitis is a promising new treatment modality. Initial studies show that it is more effective for superficial rather than deep infections and for bacterial rather than fungal infections. Conclusions: Corneal cross-linking is a procedure with an expanding list of indications from the treatment of corneal ectasias to infective keratitis. While the standard Dresden protocol is established as the gold standard treatment for progressive keratoconus, the more recent protocols may require further refinements, investigative and long-term studies.

KEYWORDS

Cornea collagen cross-linking, post-LASIK ectasia, keratoconus, infective keratitis

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Kopaenko A. I., Rasin O. G. CORNEAL COLLAGEN CROSS-LINKING – CURRENT TRENDS IN PRACTICE APPLICATIONS // Tavricheskiy Mediko-Biologicheskiy Vestnik. 2022. no. 3. pp. 98-107. DOI: https://doi.org/10.29039/2070-8092-2020-23-3-98-107. (Date of access 09.11.2026).

MLA

A. Kopaenko, Rasin O. G.. "CORNEAL COLLAGEN CROSS-LINKING – CURRENT TRENDS IN PRACTICE APPLICATIONS." Tavricheskiy Mediko-Biologicheskiy Vestnik 23.3 (2022): 98-107. DOI: https://doi.org/10.29039/2070-8092-2020-23-3-98-107.

APA

Kopaenko A. I., Rasin O. G. (2022). CORNEAL COLLAGEN CROSS-LINKING – CURRENT TRENDS IN PRACTICE APPLICATIONS. Tavricheskiy Mediko-Biologicheskiy Vestnik, 23(3), 98-107. https://doi.org/10.29039/2070-8092-2020-23-3-98-107

Chicago

A. Kopaenko, Rasin O. G.. "CORNEAL COLLAGEN CROSS-LINKING – CURRENT TRENDS IN PRACTICE APPLICATIONS." Tavricheskiy Mediko-Biologicheskiy Vestnik 23, no. 3 (2022): 98-107. https://doi.org/10.29039/2070-8092-2020-23-3-98-107.

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{{cite journal | author = Kopaenko A. I., Rasin O. G. | title = CORNEAL COLLAGEN CROSS-LINKING – CURRENT TRENDS IN PRACTICE APPLICATIONS | journal = Tavricheskiy Mediko-Biologicheskiy Vestnik | year = 2022 | volume = 23 | issue = 3 | pages = 98-107 | doi = 10.29039/2070-8092-2020-23-3-98-107 }}

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