Yalta, Simferopol, Russian Federation
In treatment of bronchial asthma (BA), it is recommended to use additional non-medicinal methods that aect various links in pathogenesis of asthma, increasingeectiveness of treatment and level of its control. The aim - evaluate laboratory eects of use of dry carbon dioxide baths (DCDB) in combination with grape polyphenols in patients with asthma during sanatorium treatment. Material and methods. Patients with asthma (n=50) underwent spa-treatment at the Sechenov Institution, in Yalta. Group 1 (n=25) included patients who, in addition to classical spa-treatment, received DCDB and grape polyphenol, group 2 - classical treatment. Blood markers before and after treatment were studied: bacterial permeability increasing protein (BPI), lipopolysaccharide-binding protein (LSB), lipopolysaccharide (LPS), soluble form of CD14 protein (sCD14), zonulin, C-reactive protein (CRP). Results. In both groups, the BPI marker signicantly increased (in group 1 from 57.6 pg/ml before, 95.0 pg/ml after, in group 2 – 64.9 pg/ml and 88.3 pg/ml, respectively), sCD14 (in both groups was initially 0, in group 1 it increased to 7.21 pg/ml, in group 2 up to 6.98 pg/ml). Zonulin in group 1 increased after treatment to 40.7 ng/ml. In group 2, it increased to 127.5 ng/ml. Conclusion. spa-treatment is accompanied by an increase in endotoxin-protective systems (BPI) and endotoxin-releasing systems (zonulin and sCD14) against the background of stable markers of endotoxin translocation into the bloodstream (LPS with LSB) and an indicator of systemic inammation. The use of DCDB and grape polyphenol concentrate in patients with BA, who had COVID-19, during spa-treatment slows the increasing of zonulin.
bronchial asthma, sanatorium treatment, COVID-19, endotoxin-binding systems, dry carbon dioxide baths, grape polyphenols
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