Astrakhan, Astrakhan, Russian Federation
Numerous studies show the advantage of sheltering the liver wounds with a flap, cut from the serous-muscular tissue of the stomach (SMFS). To increase the efficiency of this method, it is proposed to evaluate changes in metabolism in the parenchyma of the liver under the influence of the cytoprotector of sodium dichloracetate (SDA). The aim of the study was to improve the results of surgical treatment of traumatic liver injury in rabbits under the action of the cytoprotector sodium dichloroacetate by studying the biochemical indicators of liver hypoxia. Material and methods. For experiments, 30 rabbits were used, distributed into 6 groups. After surgery of hepatorrhaphy and hepatoplasty over the next seven days, dichloracetate or sodium chloride intramuscularly administered intramuscularly. To assess the state of the liver, after such operations, the activity of transfers, the enzyme glycolysis, the concentration of the alpha- fetoprotein liver marker was evaluated. Results. The curves of AST, ALT and LDH activity confirmed a higher rate of liver wound recovery after their covering with SMFS than with hepatorrhaphy. For the first time, a tendency for a faster linear decrease in the activity of AST, ALT and LDH against the background of DCA correction was shown. It has been established that the introduction of DCA significantly increases the levels of AFP in all terms for observation after hepatorrhaphy and hepatoplasty operations, and the concentration of AFP allows us to differentiate the SMFS from hepatorrhaphy on only the 7th day. Conclusion. As a result of the conducted study, a significant advantage of hepatoplasty of the LVSM compared to hepatorrhaphy was established and the role of sodium dichloroacetate in the correction of postoperative liver metabolic disorders was determined. The pyruvate dehydrogenase kinase inhibitor sodium dichloroacetate can be recommended for widespread use as a new effective drug in experimental liver surgery.
experimental liver injury, gastric seromuscular flap, sodium dichloroacetate, blood serum, ALT, AST, LDH activities, alpha-fetoprotein concentration.
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