Given the high tropism of influenza and parainfluenza viruses to the vascular endothelium and the resulting high incidence of complications, the study of the endothelioprotective effect of antiviral agents is relevant. The aim of the study was to evaluate the endothelioprotective effect of certain antiviral agents in conditions of experimental endothelial dysfunction. Material and methods. Endothelial dysfunction was modeled on male C57BL/6 mice by injection of a solution of nitro-L-arginine methyl ester (intraperitoneally, 25 mg/kg, 7 days). Antiviral drugs rimantadine, oseltamivir, riamilovir, umifenovir, carboxymethylcellulose and gossypol copolymer were administered orally for 7 days after modeling endothelial dysfunction. Further, changes in the concentration of matrix metalloproteinases 2 and 9, endothelial and inducible nitric oxide synthases were evaluated in the supernatant of the abdominal aorta. Results. The study showed that the administration of a carboxymethylcellulose and gossypol copolymer, rimantadine and umifenovir to animals did not lead to significant changes in the concentration of metalloproteinases and isoenzymes of nitric oxide synthase. At the same time, against the background of the administration of oseltamivir and riamilovir, a significant de crease in the content of matrix metalloproteinases in the vessel supernatant was observed by (type 2 - 26.3% (p<0.05) and 20.4% (p<0.05); type 9 by 41.0% (p<0.05) and 19.5% (p<0.05), respectively) and inducible nitric oxide synthase (by 62.5% (p<0.05) and 57.2% (p<0.05)), while the concentration of the endothelial isoform, on the contrary, increased (by 64.5% (p<0.05) and 40.0% (p<0.05)). Conclusion. The study showed that the use of riamilovir and oseltamivir in animals with experimental endothelial dysfunction is accompanied by the development of endothelioprotective effects.
endothelial dysfunction, metalloproteinases, nitric oxide synthases, antiviral drugs
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