The aim of this work is to study the effect of dispersed carbohydrate nutrition on the state of hard toofh tissues, gum tissue, bone tissue of the alveolar process of the jaws, and the gastric mucosa of rats. Material and methods. The studies were performed on 15 white Wistar rats. The condition of the teeth (the number and depth of carious cavities), the degree of atrophy of the alveolar process of the jaws were assssed. Biochemical methods were used to determine elastase activity and total proteolytic activity, alkaline and acid phosphatase, calcium and phosphorus concentration in alveolar bone homogenates, calculating of the ratio of calcium to phosphate concentration; in gingival homogenates, malonialdehyde content and catalase activity, inflammation markers (elastase activity, general proteolytic activity). Results. Highly sucrose refined diet formed morphological changes in the main structural components of the gastric mucosa of rats, increased the intensity of caries and the severity of the carious process, increased the degree of atrophy of the alveolar process of the jaws. In the bone tissue of the jaws, a significant decrease in the total proteolytic activity was determined; an increase in the activity of acid and alkaline phosphatase was noted. In the gingival tissues, a sharp intensification of lipid peroxidation (an increase in the content of malondialdehyde) was detected against the background of suppression of antioxidant protection in terms of catalase activity.
diet, bone metabolism, markers of inflammation, periodontal tissues
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