Russian Federation
The aim of the study was to assess heart rate variability in children with a ventricular septal defect (VSD). Material and methods: Holter monitoring was performed in patients with ventricular septal defect from 3 to 18 years of age with an assessment of the temporal and spectral parameters of heart rate variability. Conclusion: in children with VSD, a decrease in the parameters of the temporal analysis of heart rate variability compared with healthy peers (p <0.05) was observed, more pronounced in patients with operative correction of the defect, as well as an increase in the low-frequency spectrum power (LF) as an indicator of amplification sympathetic effects on heart rate. A statistically significant correlation was found between the SDNN, SDANNi parameters and the pressure levels in the right ventricle and pulmonary artery (ρ = 0.5, p <0.01) in the group of patients with benign VSD without operative correction of the defect. The decrease in indicators of the temporal parameters of heart rate variability was inversely correlated with an increase in the postoperative period. Conclusions: in children who underwent surgical closure of the VSD, there was a disturbed heart rate variability, which had an inverse correlation with the duration of the postoperative period
children, interventricular septal defect, heart rate variability
1. Baevskiy R. M. Variabel'nost' serdechnogo ritma v kosmicheskoy medicine. Ritm serdca i tip vegetativnoy regulyacii v ocenke urovnya zdorov'ya naseleniya i funkcional'noy podgotovlennosti sportsmenov. Izhevsk; 2016:15-19.
2. Lammers A., Kaemmerer H., Hollweck R. Impaired cardiac autonomic nervous activity predicts sudden cardiac death in patients with operated and unoperated congenital cardiac disease. J Thorac Cardiovasc Surg. 2006;132:647-655. doihttps://doi.org/10.1016/j.jtcvs.2006.03.057
3. Bokeriya O. L., Vul'f K. A., Shvarc V. A. Variabel'nost' ritma serdca pri defekte mezhpredserdnoy peregorodki. Novosti hirurgii. 2017;25(4):421-430. doihttps://doi.org/10.18484/2305-0047.2017.4.421
4. Teplyakov A. T., Lukinov A. V., Levshin A. V., Rybal'chenko E. V., Kuznecova A. V. Vozmozhnost' neinvazivnoy diagnostiki koronarnogo resteno za pri ocenke dinamiki pokazateley variabel'nosti ritma serdca. Klinicheskaya medicina. 2010; 88(3):21-26.
5. Johnston B. W., Barrett-Jolley R., Krige A., Welters, I. D. Heart rate variability: Measurement and emerging use in critical care medicine. Journal of the Intensive Care Society. 2020;21(2):148-157. doihttps://doi.org/10.1177/1751143719853744.
6. Heiberg J., Eckerstrcm F., Rex C. E., Maagaard M., Mshlgaard H., Redington A. Heart rate variability is impaired in adults a牥er closure of ventricular septal defect in childhood: a novel 浯nding associated with right bundle branch block. Int. J. Cardiol. 2019;274:88-92.
7. Bakari S., Koca B., Oztunz F., Abuhandan M. Variabel'nost' serdechnogo ritma u pacientov s defektom mezhpredserdnoy peregorodki i zdorovyh detey. J Cardiol. 2013;61:436-439. doihttps://doi.org/10.1016/j.jjcc.2013.01.014
8. Massin M. M., Derkenne B., von Bernuth G. Heart Rate Behavior in Children with Atrial Septal Defect. Cardiology. 1998;90:269-273. doihttps://doi.org/10.1159/000006857
9. Horner S. M., Murphy C. F., Coen B. Contribution to heart rate variability by mechanoelectric feedback.Stretch of the sinoatrial node reduces heart rate variability.Circulation.1996; 94:1762-1767. doihttps://doi.org/10.1161/01.CIR.94.7.1762
10. Hata T., Mano S., Kusuki M. Difference in autonomic nervous control between ventricular septal defect and atrial septal defect based on heart rate variability. Pacing Clin Electrophysiol. 2007;30(Suppl1):S212-S214.doihttps://doi.org/10.1111/j.1540-8159.2007.00640.x
11. Heragu N. P., Scott W. A. Heart rate variability in healthy children and in those with congenital heart disease both before and after operation. Am J Cardiol.1999; 83:1654-1657. doihttps://doi.org/10.1016/S0002-9149(99)00173-3.
12. Makarov L. M. Holterovskoe monitorirovanie. 4-e izd. M.: ID «MEDPRAKTIKA-M»; 2017.
