In this work, we determined and studied the incidence of Down syndrome (DS) in the Republic of Crimea (RC) over a ten-year period (2011-2020). To do this, we analyzed the annual birth rate data in the region and 478 registered cases of DS (249 newborns and 229 eliminated fetuses with the established karyotype of trisomy 21). The incidence of diabetes in the Republic of the Crimea during the study period averaged 2.18 per 1000 newborns with a statistically significant increase in indicators (1.67 in 2011 - 3.32 in 2020). At the same time, the incidence of diabetes in newborns decreased dynamically throughout the study period (from 1.50 to 0.98) and since 2015 for the first time became less than in eliminated fetuses, the incidence of which increased accordingly (from 0.17 in 2011 to 2.33 in 2020) due to timely prenatal diagnosis.
Down syndrome, frequency of occurrence, newborns, fetuses
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