Новосибирский национальный исследовательский государственный университет
В статье представлен обзор современных данных о бифидобактериях, их морфологии, классификации и функциональных характеристиках. Рассматривается их влияние на здоровье человека, включая модуляцию иммунитета, участие в метаболических процессах и защиту кишечного барьера. Особое внимание уделено видам Bifidobacterium bifidum, B. longum, B. breve и B. adolescentis, их применению в пробиотиках и перспективам дальнейших исследований. Описаны их терапевтические свойства, включая использование в профилактике и лечении заболеваний желудочно-кишечного тракта (ЖКТ), метаболических и иммунных нарушений. Также обсуждаются перспективы разработки новых пробиотических препаратов и их клиническое применение.
бифидобактерии, микробиом, пробиотики, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium adolescentis, кишечная микрофлора.
1. Новик Г. И. Бифидобактерии: научные основы практического использования / Г. И. Новик // Проблемы здоровья и экологии. – 2006. – № 3(9). – С. 144–151.
2. Sharma V. Exploration of survival traits, probiotic determinants, host interactions, and functional evolution of bifidobacterial genomes using comparative genomics /V. Sharma, F. Mobeen, T. Prakash // Genes.
3. Itoh K. Exploring the Potential of Humoral Immune Response to Commensal Bifidobacterium as a Biomarker for Human Health, including Both Malignant and Non-Malignant Diseases: A Perspective on
4. Hidalgo-Cantabrana C. Bifidobacteria and their health-promoting effects / C. Hidalgo-Cantabrana, S. Delgado, L. Ruiz [et al.] // Microbiology Spectrum. – 2017. – Vol. 5, No 3. – P. 1–19.
5. Чаплин А. В. Изучение видового разнообразия бактерий рода Bifidobacterium кишечной микрофлоры с использованием метода MALDI-TOF масс-спектрометрии / А. В. Чаплин, А. Г. Бржозовский
6. Lugli G. A. Investigation of the evolutionary development of the genus Bifidobacterium by comparative genomics / G. A. Lugli, C. Milani, F. Turroni [et al.] // Applied and environmental microbiology. – 2014. – Vol. 80
7. Forster S. C. A human gut bacterial genome and culture collection for improved metagenomic analyses / S. C. Forster, N. Kumar, B. O. Anonye [et al.] // Nat. Biotechnol. – 2019. – Vol. 37, No 2. – P. 186–192.
8. Бутенко Д. С. Влияние экзометаболитов Bifidobacterium bifidum на баланс про- и противовоспалительных цитокинов / Д. С. Бутенко // FORCIPE. – 2021. – № 4(S1). – C. 530–531.
9. Turroni F. Bifidobacterium bifidum: A Key Member of the Early Human Gut Microbiota / F. Turroni, S. Duranti, C. Milani [et al.] // Microorganisms. – 2019. – Vol. 7, No. 11. – P. 544.
10. Куклина Е. М. С. Il-17-продуцирующие регуляторные т-лимфоциты – супрессоры или эффекторы? / Е. М. Куклина, Н. С. Глебездина // Ученые записки Казанского университета.Серия Естественные
11. Lu J. Probiotics and Non-Alcoholic Fatty Liver Disease: Unveiling the Mechanisms of Lactobacillus plantarum and Bifidobacterium bifidum in Modulating Lipid Metabolism, Inflammation, and Intestinal
12. Wong C. B. Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: Modulation of gut microbiome as the principal action / C. B. Wong, T. Odamaki, J. Z. Xiao // J. Funct. Foods.
13. Blanco G. Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective / G. Blanco, L. Ruiz
14. Артюхова C. И. Изучение биотехнологических свойств штаммов Bifidobacterium longum для производства биологически активных добавок / C. И. Артюхова, О. А. Зверева // Международный журнал
15. Longhi G. Highly conserved bifidobacteria in the human gut: Bifidobacterium longum subsp. longum as a potential modulator of elderly innate immunity / G. Longhi, G. A. Lugli, M. G. Bianchi [et al.]
16. Dargenio V. N. Impact of Bifidobacterium longum Subspecies infantis on Pediatric Gut Health and Nutrition: Current Evidence and Future Directions / V. N. Dargenio, F. Cristofori, V. F. Brindicci [et al.]
17. Yu J. Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma / J. Yu, P. Zhu, L. Shi // Cell. Host. Microbe. – 2024 – Vol. 32, No 1. – P. 131–144.
18. Громова О. А. Пробиотический штамм Bifidobacterium Longum BB36 –нутрицевтик широкого профиля / О. А. Громова, И. Ю. Торшин // Экспериментальная и клиническая гастроэнтерология. – 2022.
19. Sharma M. Recent developments in probiotics: an emphasis on Bifidobacterium / M. Sharma, A. Wasan, R. K. Sharma // Food Biosci. – 2021. – No 41.
20. Kujawska M. Exploring the Potential Probiotic Properties of Bifidobacterium breve DSM 32583 – A Novel Strain Isolated from Human Milk / M. Kujawska, K. Neuhaus, C. Huptas [et al.] // Probiotics & Antimicro.
21. Naklong K. Microencapsulation of Bifidobacterium breve to Enhance Microbial Cell Viability in Green Soybean Yogurt / K. Naklong, P. Therdtatha, N. Sumonsiri [et al.] // Fermentation. – 2023. – Vol. 9, No 3.
22. Bozzi Cionci N. Therapeutic Microbiology: The Role of Bifidobacterium breve as Food Supplement for the Prevention/Treatment of Paediatric Diseases / N. Bozzi Cionci, L. Baffoni, F. Gaggмa [et al.]
23. Wong C. B. Exploring the Science behind Bifidobacterium breve M-16V in Infant Health / C. B. Wong, N. Iwabuchi, J. Z. Xiao // Nutrients. – 2019. – Vol. 11, No 8. – P. 1724.
24. Leser T. Bifidobacterium adolescentis – a beneficial microbe / T. Leser, A. Baker // Beneficial microbes. – 2023. – Vol. 14, No 6. – P. 525–551.
25. Козин С. В. Антиоксидантный и анксиолитический эффекты Bifidobacterium adolescentis и Lactobacillus acidophilus в условиях нормобарической гипоксии с гиперкапнией/С. В. Козин, А. А. Кравцов,
26. Ших Е. В. Перспективы пробиотических штаммов бифидобактерий и энтерококков в лечении и профилактике заболеваний гастроэнтерологического профиля/Е. В. Ших, А. А. Махова
27. Duranti S. Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA / S. Duranti, L. Ruiz, G. A. Lugli [et al.] // Sci. Rep. – 2020. – No 10. – P. 14112.
28. Li B. Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function / B. Li, H. Wang, M. Wang [et al.] // Frontiers in microbiology. – 2025. – No. 15.
29. van der Lelie D. Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis / D. van der Lelie, A. Oka, S. Taghavi [et al.] // Nat. Commun. – 2021. –
30. Chen J. Recent Development of Probiotic Bifidobacteria for Treating Human Diseases / J. Chen, X. Chen, C. L. Ho // Front. Bioeng. Biotechnol. – 2021. – Vol. 22, No 9. – P. 770248.
31. Cheng J. Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review / J. Cheng, A. Laitila, A. C. Ouwehand // Front. Nutr. – 2021. – No 8. – P. 790561.
32. Arboleya S. Gut Bifidobacteria Populations in Human Health and Aging / S. Arboleya, C. Watkins, C. Stanton [et al.] // Frontiers in Microbiology. – 2016. – No 7.
33. Yoon S. J. Bifidobacterium-derived short-chain fatty acids and indole compounds attenuate nonalcoholic fatty liver disease by modulating gut-liver axis / S. J. Yoon, J. S. Yu, B.H.Min [et al.]/Frontiers in microbiology.
34. Markowiak-Kopeć P. The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome / P. Markowiak-Kopeć, K. Śliżewska // Nutrients.– 2020.– Vol.12, No 4.– P. 1107.
35. Ordoсez-Rodriguez A. Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review / A. Ordoсez-Rodriguez, P. Roman, L. Rueda-Ruzafa [et al.] // International journal of environmental
36. Cui Z. Bifidobacterium species serve as key gut microbiome regulators after intervention in gestational diabetes mellitus / Z. Cui, S. Wang, J. Niu [et al.] // BMC Microbiol. – 2024. – No 24. – P. 520.
37. Fusco W. Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota / W. Fusco, M. B. Lorenzo, M. Cintoni [et al.] // Nutrients. – 2023. – Vol. 15, No 9. – P. 2211.
38. Ratajczak W. Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs) / W. Ratajczak, A. Rył, A. Mizerski [et al.] // Acta biochimica Polonica. – 2019. – Vol. 66, No 1. – P. 1–12.
39. Shaw C. The Yin and Yang of pathogens and probiotics: interplay between Salmonella enterica sv. Typhimurium and Bifidobacterium infantis during co-infection / C. Shaw, B. C. Weimer, R. Gann [et al.]
40. Fukuda S. Bifidobacteria can protect from enteropathogenic infection through production of acetate / S. Fukuda, H. Toh, K. Hase [et al.] // Nature. – 2011. – Vol. 469, No 7331. – P. 543–547.
41. O'Callaghan A. Bifidobacteria and Their Role as Members of the Human Gut Microbiota / A. O'Callaghan, D. van Sinderen // Frontiers in microbiology. – 2016. – No 7. – P. 925.
42. Rahila Y. Bifidobacterium sp as Probiotic Agent – Roles and Applications / Y. Rahila, B. V. Pradeep // J. Pure. Appl. Microbiol. – 2019. – Vol. 13, No 3. – P. 1407–1417.
43. Devi T. B. Low Bifidobacterium Abundance in the Lower Gut Microbiota Is Associated with Helicobacter pylori-Related Gastric Ulcer and Gastric Cancer / T. B. Devi, K. Devadas, M. George [et al.]
44. Chenoll E. Novel probiotic Bifidobacterium bifidum CECT 7366 strain active against the pathogenic bacterium Helicobacter pylori / E. Chenoll, B. Casinos, E. Bataller [et al.] // Applied and environmental
45. Bernini L. J. Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome / L. J. Bernini
46. Tang J. The therapeutic value of bifidobacteria in cardiovascular disease / J. Tang, Y. Wei, C. Pi [et al.] // NPJ Biofilms Microbiomes. – 2023. – No 9. – P. 82.
47. Maruta H. Effects of Bifidobacterium-Fermented Milk on Obesity: Improved Lipid Metabolism through Suppression of Lipogenesis and Enhanced Muscle Metabolism / H. Maruta, Y. Fujii, N. Toyokawa [et al.]
48. Leуn Aguilera X. E. Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution / X. E. Leуn Aguilera, A. Manzano, D. Pirela [et al.] // Journal of personalized medicine.–2022. – Vol. 12
49. Procaccianti G. Bifidobacterium in anticancer immunochemotherapy: friend or foe? / G. Procaccianti, S. Roggiani, G. Conti [et al.] // Microbiome research reports. – 2023. – Vol. 2, No 3. – P. 24.
50. Pei B. Bifidobacterium modulation of tumor immunotherapy and its mechanism / B. Pei, S. Peng, C. Huang [et al.] // Cancer immunology, immunotherapy. – 2024. – Vol. 73, No 5. – P. 94.
51. Shang F. Bifidobacterium longum suppresses colorectal cancer through the modulation of intestinal microbes and immune function / F. Shang, X. Jiang, H. Wang [et al.] // Frontiers in microbiology. – 2024.
52. Ugai S. Long-term yogurt intake and colorectal cancer incidence subclassified by Bifidobacterium abundance in tumor / S. Ugai, L. Liu, K. Kosumi [et al.]//Gut Microbes. – 2025. – Vol. 17, No 1. – P. 2452237.
53. Azuma N. Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial / N. Azuma, T. Mawatari, Y. Saito
54. Zhu G. Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome / G. Zhu, J. Zhao, H. Zhang [et al.] //Nutrients. – 2021. – Vol. 13, No 5.
55. Wang H. Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress / H. Wang, C. Braun, E. F. Murphy [et al.] // The American journal of gastroenterology. – 2019.
56. Patterson E. Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: a randomized, double-blind, placebo-controlled clinical trial / E. Patterson, H. T. T. Tan
57. Huda M. N. Bifidobacterium Abundance in Early Infancy and Vaccine Response at 2 Years of Age / M. N. Huda, S. M. Ahmad, M. J. Alam [et al.] // Pediatrics. – 2019. – Vol. 143, No 2. – P. 1489.
58. Abdelhamid M.Probiotic Bifidobacterium breve MCC1274 Mitigates Alzheimer's Disease-Related Pathologies in Wild-Type Mice / M. Abdelhamid, C. Zhou, C. G. Jung [et al.]//Nutrients. – 2022. – Vol. 14, No 12.
59. Sibanda T. Bifidobacterium species viability in dairy-based probiotic foods: challenges and innovative approaches for accurate viability determination and monitoring of probiotic functionality
60. Ku S. The role of Bifidobacterium in longevity and the future of probiotics / S. Ku, M. A. Haque, M. J. Jang [et al.] // Food science and biotechnology. – 2024. – Vol. 33, No 9. – P. 2097–2110.
