В экспериментах на крысах изучали эффективность аргинина (АРГ, 100 мг/кг/сутки), умеренной динамической физической нагрузки (ФН) и их комбинации в компенсации расстройств сократительной функции m. tibialis anterior, вызванных введением дексаметазона (ДМ, 0,25 мг/кг/1 раз в 2-е суток, в течение 10–60 дней). Установлено, что АРГ, ФН и их комбинация, используемые в комплексе с ДМ, предотвратили характерное для ДМ-групп ухудшение резистентности мышцы к утомлению, но неоднозначно сказывались на сократительных и эргометрических ее параметрах: АРГ полностью компенсировал их ухудшение, вызванное ДМ; спустя первые 10 дней применения ДМ с ФН наблюдалось ухудшение амплитудных и временных параметров сокращения мышцы, тогда как по завершении 2-месячного периода – их нормализация. АРГ, применяемый в комплексе с ФН и ДМ, предотвратил типичное для ДМ+ФН-групп ухудшение амплитудных, но не временных параметров сокращения СМ.
скелетная мышца, дексаметазон, стероидная миопатия, аргинин, физическая нагрузка, крысы
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