В обзоре представлены данные о роли оксидантного стресса и цитокинового дисбаланса в патогенезе хронической мигрени. Анализировались литературные источники, датированные с 2000 по 2023 гг., на сайтах Pubmed, Springer, eLIBRARY, на русском и английском языках. Целью обзора являлось обобщение имеющихся сведений о значение оксидантного стресса и цитокинового дисбаланса в патогенезе хронической мигрени. Научные данные последних лет убедительно доказывают, что с молекулярной точки зрения критическая роль в этом процессе принадлежит системному оксидантному стрессу и цитокиновому дисбалансу, что можно объяснить их фундаментальной ролью в формировании центральной сенситизации – ключевого патофизиологического механизма развития, поддержания и прогрессирования хронической мигрени. Представленные выше данные позволяют сделать вывод о том, что оксидантный гомеостаз и цитокиновый дисбаланс могут служить потенциальными терапевтическими мишенями при хронической мигрени.
мигрень, патогенез, оксидантный стресс, цитокиновый дисбаланс, центральная сенситизация.
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